NanoSolveIT IATA: PBPK models and integration with the occupational exposure model

Short description

This web application enables the use of PBPK models developed in the context of the NanoSolveIT project for simulating the biodistribution of nanoparticles in humans as a result of exposure via the inhalation route. External exposure scenarios can be defined directly by the user or simulated through integration with the NanoSolveIT occupational exposure model, illustrating the combination of various nanoinformatics tools available through the NanoSolveIT computational infrastructure. This version contains a PBPK model for TiO2 nanoparticles. Additional PBPK models will be implemented in the next release of the tool.

External exposure: The user can use the Multi-box Human Exposure model output or define a custom-made scenario.

Internal exposure: Mass-time profiles are simulated using a PBPK model. Plots visualizing the results in various compartments are automatically generated.

*This work project has received funding from European Union Horizon 2020 Programme (H2020) via NanoSolveIT research infrastructure project under grant agreement nº 814572.